As a result, temperature essentially regulates all physiological processes of living organisms. All biochemical reactions have a temperature coefficient that refers to the rate of change of a biochemical reaction as a consequence of temperature increase. To quantify the heat present in an object, modern sciences use temperature (defined by the third law of thermodynamics) as a measure of the motions and vibrations of the particle constituents of the object. Many ancient cultures considered heat (fire) a classical element of nature ( 1). A thorough understanding of thermosensation not only provides key insights into sensory biology but also builds a foundation for developing better treatments for various sensory disorders. We also discuss the fundamental coding strategies of thermosensation at the circuit level.
Here, we present the current understanding of thermosensation at the molecular and cellular levels. Additionally, thermosensory neurons and circuits in different species appear to adopt similar logic to transduce and process temperature information.
For example, conserved molecular thermosensors, including thermosensitive channels and receptors, act as the initial detectors of temperature changes across taxa. elegans, have revealed many exciting principles of thermosensation. Studies from animal models, such as mouse, Drosophila, and C.
Due to the profound impact of temperature on physiology and behavior, animals and humans have evolved sophisticated mechanisms to detect temperature changes. Temperature is a universal cue and regulates many essential processes ranging from enzymatic reactions to species migration.
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